Edexcel A-Level Psychology 9PS0
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Biological Psychology
Contemporary study: Van den Oever et al. (2008)
- 3 things to know
- Papers 1 and 3
Overview
Recall questions on the rat self-administration procedure, AMPA receptor plasticity in the prefrontal cortex, and the implications for relapse.
What you need to know
Answer each one before you reveal it.
In Van den Oever et al. (2008), what behavioural procedure was used to model addiction and relapse?
Which brain area was the focus of Van den Oever et al. (2008)?
Questions from this subtopic
Each one with the model answer underneath.
- 1
What did Van den Oever et al. (2008) investigate?
Model answer
The role of AMPA receptor plasticity in the prefrontal cortex in cue-induced relapse to heroin-seeking.
- 2
What species was used in Van den Oever et al. (2008)?
Model answer
Rats.
- 3
What behavioural procedure was used to model addiction and relapse?
Model answer
Rats self-administered heroin, the behaviour was extinguished, and relapse was then triggered by re-presenting the drug-associated cues.
- 4
Which brain area was the focus of Van den Oever et al. (2008)?
Model answer
The medial prefrontal cortex.
- 5
What is synaptic plasticity?
Model answer
The strengthening or weakening of synaptic connections with experience, which is the physical basis of learning.
- 6
What did the study find about AMPA receptors during cue-induced relapse?
Model answer
Their composition and trafficking changed in the prefrontal cortex, and interfering with that change reduced cue-induced heroin-seeking.
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