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Biological Psychology

Contemporary study: Van den Oever et al. (2008)

  • 3 things to know
  • Papers 1 and 3

Overview

Recall questions on the rat self-administration procedure, AMPA receptor plasticity in the prefrontal cortex, and the implications for relapse.

What you need to know

Answer each one before you reveal it.

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Who and when

What did Van den Oever et al. (2008) investigate?

Process

In Van den Oever et al. (2008), what behavioural procedure was used to model addiction and relapse?

Key term

Which brain area was the focus of Van den Oever et al. (2008)?

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    What did Van den Oever et al. (2008) investigate?

    Model answer

    The role of AMPA receptor plasticity in the prefrontal cortex in cue-induced relapse to heroin-seeking.

  2. 2

    What species was used in Van den Oever et al. (2008)?

    Model answer

    Rats.

  3. 3

    What behavioural procedure was used to model addiction and relapse?

    Model answer

    Rats self-administered heroin, the behaviour was extinguished, and relapse was then triggered by re-presenting the drug-associated cues.

  4. 4

    Which brain area was the focus of Van den Oever et al. (2008)?

    Model answer

    The medial prefrontal cortex.

  5. 5

    What is synaptic plasticity?

    Model answer

    The strengthening or weakening of synaptic connections with experience, which is the physical basis of learning.

  6. 6

    What did the study find about AMPA receptors during cue-induced relapse?

    Model answer

    Their composition and trafficking changed in the prefrontal cortex, and interfering with that change reduced cue-induced heroin-seeking.

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