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Clinical Psychology
Contemporary study: Scott-Van Zeeland et al. (2013)
- 2 things to know
- Papers 2 and 3
Overview
Recall questions on the EPHX2 gene, the sequencing and replication method, and what it contributes to explaining anorexia.
What you need to know
Answer each one before you reveal it.
What method did Scott-Van Zeeland et al. (2013) use?
Questions from this subtopic
Each one with the model answer underneath.
- 1
What did Scott-Van Zeeland et al. (2013) investigate?
Model answer
Whether variants in the EPHX2 gene are associated with anorexia nervosa.
- 2
What method did Scott-Van Zeeland et al. (2013) use?
Model answer
Targeted sequencing of candidate genes in cases and controls, followed by replication in independent samples.
- 3
Roughly how many participants were involved?
Model answer
Around 1,200 anorexia cases and a comparable number of controls, with further replication samples.
- 4
What does the EPHX2 gene do?
Model answer
It encodes an enzyme involved in cholesterol and lipid metabolism.
- 5
What was the main finding of Scott-Van Zeeland et al. (2013)?
Model answer
Variants in EPHX2 were associated with anorexia nervosa and with altered cholesterol metabolism in those affected.
- 6
Why was the link to lipid metabolism theoretically interesting?
Model answer
Because it suggests a biological pathway relating anorexia to the body's handling of fat, rather than to appetite regulation alone.
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