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Clinical Psychology

Contemporary study: Scott-Van Zeeland et al. (2013)

  • 2 things to know
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Overview

Recall questions on the EPHX2 gene, the sequencing and replication method, and what it contributes to explaining anorexia.

What you need to know

Answer each one before you reveal it.

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Who and when

What did Scott-Van Zeeland et al. (2013) investigate?

Who and when

What method did Scott-Van Zeeland et al. (2013) use?

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    What did Scott-Van Zeeland et al. (2013) investigate?

    Model answer

    Whether variants in the EPHX2 gene are associated with anorexia nervosa.

  2. 2

    What method did Scott-Van Zeeland et al. (2013) use?

    Model answer

    Targeted sequencing of candidate genes in cases and controls, followed by replication in independent samples.

  3. 3

    Roughly how many participants were involved?

    Model answer

    Around 1,200 anorexia cases and a comparable number of controls, with further replication samples.

  4. 4

    What does the EPHX2 gene do?

    Model answer

    It encodes an enzyme involved in cholesterol and lipid metabolism.

  5. 5

    What was the main finding of Scott-Van Zeeland et al. (2013)?

    Model answer

    Variants in EPHX2 were associated with anorexia nervosa and with altered cholesterol metabolism in those affected.

  6. 6

    Why was the link to lipid metabolism theoretically interesting?

    Model answer

    Because it suggests a biological pathway relating anorexia to the body's handling of fat, rather than to appetite regulation alone.

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