What was the aim of Carlsson et al.'s (2000) work on schizophrenia?

To re-evaluate the neurochemical basis of schizophrenia, moving beyond the classic dopamine hypothesis to consider how several neurotransmitter systems interact, and what this means for treatment.

What research method did Carlsson et al. (2000) use?

It was a review that drew together findings from animal studies and human pharmacological research on neurotransmitter interactions.

What was Carlsson et al.'s central argument about the cause of schizophrenia?

That schizophrenia is not caused by dopamine alone but by interactions within networks of neurotransmitters, including glutamate, GABA and serotonin, that regulate one another.

What were the therapeutic implications of Carlsson et al.'s (2000) review?

That new drugs could target glutamate and other transmitter systems rather than dopamine alone, potentially treating a wider range of symptoms with fewer side effects.

What did Carlsson et al. (2000) argue about schizophrenia and dopamine?

That the simple dopamine hypothesis is insufficient, and that glutamate and other transmitter systems interact with dopamine to produce symptoms.

Edexcel A-Level Psychology 9PS0

Social Psychology

Topic overview Agency theory and social impact theory Milgram's research into obedience Factors affecting obedience and resistance Social identity theory and realistic conflict theory Factors affecting prejudice and discrimination Individual differences in obedience and prejudice Developmental psychology in obedience and prejudice Designing questionnaires and interviews Types of interview and question Alternate and null hypotheses Sampling techniques Quantitative and qualitative data Analysing quantitative data Thematic analysis of qualitative data The BPS code of ethics and conduct Risk management in psychological research Classic study: Sherif et al. (1954) Robbers Cave Contemporary study: Burger (2009)Contemporary study: Reicher and Haslam (2006)Contemporary study: Cohrs et al. (2012)Key question in social psychology Designing the practical investigation Analysing and reporting the practical investigation Ethics and practical issues in social psychology Nature-nurture, social control and reducing prejudice Reductionism and comparing explanations Culture, gender and social sensitivity

Cognitive Psychology

Topic overview The working memory model The multi-store model of memory Episodic and semantic long-term memory Reconstructive memory and schema theory Individual differences in memory Developmental psychology in memory Laboratory and field experiments Independent and dependent variables Experimental and null hypotheses One-tailed and two-tailed tests Experimental designs Operationalisation, extraneous and confounding variables Order effects and counterbalancing Situational and participant variables Objectivity, reliability and validity Demand characteristics and experimenter effects Measures of central tendency and dispersion Graphical presentation of data Mann-Whitney U and Wilcoxon Significance, critical values and errors Case studies of brain-damaged patients Classic study: Baddeley (1966)Contemporary study: Schmolck et al. (2002)Contemporary study: Steyvers and Hemmer (2012)Contemporary study: Sebastián and Hernández-Gil (2012)Key question in cognitive psychology Practical investigation in cognitive psychology Issues and debates in cognitive psychology

Biological Psychology

Learning Theories

Topic overview The main features of classical conditioning Pavlov's experiment with salivation in dogs The main features of operant conditioning Properties and schedules of reinforcement Behaviour modification and shaping The main features of social learning theory The four stages of social learning Bandura's original Bobo doll experiments Bandura (1965) and vicarious reinforcement How learning theories explain phobias Systematic desensitisation and flooding Individual differences in learning theories Developmental psychology in learning theories Observational research with humans Animal research and its ethics Chi-squared and levels of measurement Thematic analysis in learning research The scientific status of psychology Classic study: Watson and Rayner (1920) Little Albert Contemporary study: Becker et al. (2002)Contemporary study: Bastian et al. (2011)Contemporary study: Capafons et al. (1998)Key question in learning theories Practical investigation in learning theories Issues and debates in learning theories

Clinical Psychology

Topic overview Diagnosing mental disorders and the four Ds The DSM and ICD classification systems Symptoms and features of schizophrenia Explanations of schizophrenia Anorexia nervosa: symptoms and explanations Obsessive-compulsive disorder: symptoms and explanations Unipolar depression: symptoms and explanations Treatments for schizophrenia and the second disorder Individual differences in clinical psychology Developmental psychology in clinical psychology HCPC guidelines for clinical practitioners Researching mental health Case studies in clinical psychology Interviews in clinical psychology Choosing an inferential test Descriptive statistics, levels of measurement and significance Thematic analysis and grounded theory Classic study: Rosenhan (1973)Contemporary study: Carlsson et al. (2000)Contemporary study: Kroenke et al. (2008)Contemporary study: Williams et al. (2013)Contemporary study: Scott-Van Zeeland et al. (2013)Contemporary study: Guardia et al. (2012)Contemporary study: Masellis et al. (2003)Contemporary study: March et al. (2004) POTS Key question in clinical psychology Practical investigation in clinical psychology Issues and debates in clinical psychology Comparing the classic studies

Criminological PsychologyApplication

Topic overview Biological explanations of crime Social explanations of crime The cognitive interview and ethical interviewing Psychological formulation and offence analysis Cognitive-behavioural treatments for offenders Biological treatments for offenders Factors influencing eye-witness testimony Factors influencing jury decision-making Individual differences in criminological psychology Developmental psychology in criminological psychology Research methods in criminological psychology Sample selection and techniques Reliability and validity in criminological research Objectivity, credibility and ethics in criminological research Analysing data and evaluating practical research Ethical guidelines in criminological research Classic study: Loftus and Palmer (1974)Contemporary study: Bradbury and Williams (2013)Contemporary study: Valentine and Mesout (2009)Contemporary study: Howells et al. (2005)Key question in criminological psychology Practical investigation in criminological psychology Issues and debates in criminological psychology

Child PsychologyApplication

Topic overview Bowlby's theory of attachment Ainsworth and the Strange Situation Research into deprivation Research into privation Research into day care Cross-cultural research into attachment Autism: features, explanations and therapies Individual differences in child psychology Developmental psychology in child psychology Observation in child psychology Questionnaires and interviews in child psychology Issues with self-report in child research Cross-cultural research methods The ethics of researching with children Analysing data in child psychology Classic study: van IJzendoorn and Kroonenberg (1988)Contemporary study: Cassibba et al. (2013)Contemporary study: Gagnon-Oosterwaal et al. (2012)Contemporary study: Li et al. (2013) child care timing Key question in child psychology Practical investigation in child psychology Issues and debates in child psychology

Health PsychologyApplication

Clinical Psychology

Contemporary study: Carlsson et al. (2000)

2 things to know
Papers 2 and 3

Overview

Recall questions on why the simple dopamine hypothesis was insufficient, the role of glutamate, and the therapeutic implications.

What you need to know

Answer each one before you reveal it.

Your recallNot started

Who and when

According to Carlsson et al. (2000), how does glutamate relate to dopamine in schizophrenia?

Key term

What evidence pointed to glutamate involvement in schizophrenia?

Questions from this subtopic

Each one with the model answer underneath.

1
What was the aim of Carlsson et al.'s (2000) work on schizophrenia?
Model answer
To re-evaluate the neurochemical basis of schizophrenia, moving beyond the classic dopamine hypothesis to consider how several neurotransmitter systems interact, and what this means for treatment.
2
What research method did Carlsson et al. (2000) use?
Model answer
It was a review that drew together findings from animal studies and human pharmacological research on neurotransmitter interactions.
3
What was Carlsson et al.'s central argument about the cause of schizophrenia?
Model answer
That schizophrenia is not caused by dopamine alone but by interactions within networks of neurotransmitters, including glutamate, GABA and serotonin, that regulate one another.
4
According to Carlsson et al. (2000), how does glutamate relate to dopamine in schizophrenia?
Model answer
Glutamate normally helps to control dopamine activity, so reduced glutamate function at NMDA receptors (hypoglutamatergia) can lead to dysregulated dopamine and psychotic symptoms.
5
What were the therapeutic implications of Carlsson et al.'s (2000) review?
Model answer
That new drugs could target glutamate and other transmitter systems rather than dopamine alone, potentially treating a wider range of symptoms with fewer side effects.
6
What did Carlsson et al. (2000) argue about schizophrenia and dopamine?
Model answer
That the simple dopamine hypothesis is insufficient, and that glutamate and other transmitter systems interact with dopamine to produce symptoms.

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