Why does a smoker develop a persistent cough?

Cilia are destroyed while mucus production is increased, so the only way to clear the accumulated mucus from the airways is by coughing.

Explain how the carbon monoxide in tobacco smoke reduces the oxygen supply to the tissues.

Carbon monoxide binds to the haem groups of haemoglobin far more strongly than oxygen does, forming carboxyhaemoglobin, so fewer binding sites remain available to carry oxygen.

Name the component of tobacco smoke that contains carcinogens, and state where its long-term damage is seen.

Tar, which deposits on the lining of the airways and causes mutations in the DNA of the bronchial epithelial cells, leading to lung cancer.

Name three long-term diseases of the respiratory system caused by tobacco smoke.

Chronic bronchitis, emphysema and lung cancer.

OCR A-Level Biology B H422

The Developing Cell: Cell Division and Cell Differentiation

Topic overview The cell cycle and mitosis Apoptosis in growth and repair Stem cells and cell differentiation

The Developing Individual: Meiosis, Growth and Development

Topic overview Meiosis, haploid gametes and genetic variation The stages of meiosis Antenatal care and diet in pregnancy Alcohol, smoking and monitoring fetal growth Prenatal screening and karyotypes

The Development of Species: Evolution and Classification

Topic overview Classification and the species concept Evidence for classification and DNA barcoding Phylogenetic trees, hominids and the evolution of language Human adaptations, natural selection and evolution Plant adaptations and how they are investigated Measuring biodiversity and genetic diversity

Cells and Microscopy

Topic overview Microscopy and the cell theory Blood smears, staining and microscope drawings Blood cells and their structure Magnification and measuring cells Haemocytometer cell counts and dilutions Flow cytometry in blood analysis Ultrastructure of the animal cell Plant and prokaryotic cells Membrane lipids and the fluid mosaic model Movement of molecules across membranes The roles of membranes and the secretion of proteins

Water and Its Importance in Plants and Animals

Topic overview The properties of water Water as a transport medium and the composition of body fluids Detecting and measuring sugars and proteins Monomers, polymers and the carbohydrates Osmosis and water potential

Proteins and Enzymes

Topic overview Amino acids, peptide bonds and chromatography Globular protein structure: enzymes and haemoglobin Enzyme action and the rate of reaction Blood clotting and first aid Enzymes and inhibitors in medicine Blood donation and stored blood products

Nucleic Acids

Topic overview Nucleotides, ADP and ATP The structure of DNA and its extraction DNA replication and the genetic code RNA, transcription and translation

Patterns of Inheritance

Topic overview Monogenic inheritance and genetic terminology Gene mutations and inherited disease Codominance, multiple alleles and linkage Model organisms, dihybrid crosses and the chi-squared test Chromosome mutations and genetic counselling

Population Genetics and Epigenetics

Topic overview Natural selection, sickle cell and malaria The Hardy-Weinberg principle Genetic drift, the founder effect and speciation Epigenetics and gene expression

Gene Technologies

Topic overview Post-Transcriptional Editing of mRNA Genetic modification of bacteria and insulin production The polymerase chain reaction and gel electrophoresis Haplotypes, SNPs, VNTRs and genetic engineering in eukaryotes Gene therapy and RNA interference

The Principles and Importance of Homeostasis

Topic overview Homeostatic principles, normal ranges and feedback The nervous and hormonal control of heart rate The control of body temperature and the role of thyroxine Measuring core body temperature, hypothermia and hyperthermia

The Hormonal Control of Blood Glucose and the Management of Diabetes

Topic overview The pancreas as an endocrine gland The regulation of blood glucose by negative feedback Types of diabetes and diagnostic testing Treating and managing diabetes

Kidney Functions and Malfunctions

Topic overview Excretion and the gross structure of the kidney The nephron: ultrafiltration and selective reabsorption Investigating the composition of urine, plasma and filtrate Osmoregulation and the action of ADH The kidney as an endocrine gland and kidney failure Dialysis, transplantation and the future of transplant surgery

The Cellular Basis of Cancer and Treatment

Topic overview Risk factors for non-communicable disease Cell cycle control and tumour formation Proto-oncogenes and tumour suppressor genes Epidemiological evidence, screening and genetic testing Methods used to detect cancer Treating patients with cancer

Respiratory Diseases and Treatment

Topic overview Pollutants and the respiratory system COPD, asthma and lung cancer Treating asthma and medicinal drugs from plants Clinical trials and the role of NICE

Cellular Respiration

Topic overview Glycolysis and the link reaction The Krebs cycle Oxidative phosphorylation and anaerobic respiration Respiratory substrates and respiratory quotients Measuring the rate of respiration

Metabolism and Exercise

Topic overview The consequences of exercise on the body Aerobic fitness and VO₂ max Training, F.I.T.T. factors and investigating fitness Enhancing athletic performance Haemoglobin and the transport of oxygen Oxygen dissociation curves of different respiratory pigments Oxygen deficit and oxygen debt The structure of skeletal muscle The sliding filament theory of muscle contraction

Pathogenic Microorganisms

Topic overview How pathogens cause communicable disease Tuberculosis HIV, AIDS and the structure of the virus Identifying bacteria: Gram staining and culture Epidemiology: incidence, prevalence and mortality Notifiable diseases and the control of HIV and TB

The Immune System

Topic overview Primary defences and non-specific responses B and T lymphocytes and the specific response Antibodies and testing for TB and HIV Types of immunity and allergy

Controlling Communicable Diseases

Topic overview Vaccination and vaccination programmes Problems and ethics of vaccine development and use Antibiotics and antibiotic resistance Investigating antibiotics, disinfectants and hygiene

Photosynthesis, Food Production and Management of the Environment

Topic overview Chloroplast ultrastructure and photosynthetic pigments The light-dependent stage of photosynthesis The Calvin cycle Investigating the factors affecting photosynthesis The Hill reaction and DCPIP Using TP and GP to build carbohydrates, lipids and amino acids The compensation point and crop production Microorganisms, the nitrogen cycle and biosensors Biomass transfer and efficiency in food production Ruminants in the human food chain Farms as ecosystems and the conflict with conservation Deflected succession and measuring biodiversity

The Impact of Population Increase

Topic overview Birth rate, death rate and demographic change Human impact on ecosystems and biodiversity The importance and measurement of species biodiversity Global food security and sustainable food production

Planning and Implementing Practical Work

Topic overview Designing an investigation and controlling variables Choosing apparatus and judging whether a method will work Implementing: apparatus, units and recording results

Analysing and Evaluating Practical Results

Topic overview Processing and interpreting experimental results Mathematical skills for analysing biological data Significant figures and reporting values Plotting and interpreting graphs Anomalies, limitations and refining a procedure Precision, accuracy and uncertainty

Practical Skills, Apparatus and Techniques

Topic overview Investigative approaches and working safely Following instructions, recording and presenting data Research, referencing and processing data with software Measuring mass, volume, time, temperature, length and pH Colorimeters and potometers Laboratory glassware and serial dilutions Light microscopy, graticules and biological drawing Qualitative reagents for biological molecules Chromatography and electrophoresis Aseptic technique and dissection Whole-organism responses, fieldwork sampling and data logging

Fertility and Assisted Reproduction

Topic overview The urinogenital systems and gonad histology Gametogenesis and the structure of the gametes Hormonal control of gametogenesis and the menstrual cycle Fertilisation and pregnancy testing The causes and issues of infertility Assisted reproduction techniques

The Effects of Ageing on the Reproductive System

Topic overview Ageing and the female reproductive system Managing the menopause Ageing and the male urinogenital system

Plant Reproduction

Topic overview The control of flowering Adaptations of flowers for pollination Fertilisation, seed formation and germination Cereals as staple foods

The Nervous System and the Identification and Consequences of Damage

Topic overview Organisation of the nervous system and nervous tissue The structure and function of the human brain The structure of motor, sensory and relay neurones Resting potential and the action potential Synapses and the integration of responses Reflexes, reaction times and their investigation Brain scans and the consequences of nervous system damage Drugs, brain function and dependency

Monitoring Visual Function

Topic overview The structure of the eye The retina and its role as a transducer Assessing visual function by routine eye tests

The Effect of Ageing on the Nervous System

Topic overview Alzheimer's disease: symptoms and causes The effects of ageing on the senses and memory Investigating ageing, reaction times and memory

The Heart and Monitoring Heart Function

Topic overview The need for a mass transport system Structure and dissection of the mammalian heart The cardiac cycle Initiation and coordination of the heartbeat Heart rate, pulse rate and cardiac output Electrocardiograms and emergency cardiac treatment

Transport Systems in Mammals

Topic overview The closed double circulatory system Blood vessels and their microscopic structure Tissue fluid and capillary exchange Measuring and interpreting blood pressure

Gas Exchange in Mammals and Plants

Topic overview Tissues of the mammalian gas exchange system Gas exchange in the alveoli Pulmonary ventilation and lung volumes Expired air resuscitation Gas exchange and stomata in terrestrial plants

Transport Systems in Plants

Topic overview The need for transport systems in plants Vascular tissue in roots, stems and leaves Water uptake and movement through the plant Transpiration and Its Measurement Translocation in the Phloem

Respiratory Diseases and Treatment

4 subtopics
12 things to know
Components 01, 02 and 03

What Respiratory Diseases and Treatment covers

Respiratory Diseases and Treatment is examined in all three written papers — the specification states that Components 01, 02 and 03 can each assess content from any of the five modules, so nothing is confined to one paper. It covers Pollutants and the respiratory system, COPD, asthma and lung cancer, treating asthma and medicinal drugs from plants and clinical trials and the role of NICE.

Where it is assessed

Components 01, 02 and 03

Every module can be assessed on any of the three papers.

Check the OCR specification ↗

The 4 subtopics

Each one has its own page.

What you need to know

Answer each one before you reveal it.

Your recallNot started

Key term

Describe the long-term effect of asbestos exposure on lung tissue.

Key term

Explain why a person with emphysema becomes severely breathless.

Key term

Explain the role of histamine in an asthma attack.

Key term

Give two reasons why asthma drugs are given through an inhaler rather than as a tablet.

Key term

State the purpose of a phase I clinical trial and who takes part.

Key term

State three short-term effects of inhaling an irritant pollutant on the airways.

Key term

State two side effects of taking a beta agonist.

Key term

State the purpose of a phase II clinical trial.

Key term

Explain the short-term effect of tobacco smoke on the ciliated epithelium of the airways.

Key term

Describe the changes to the airways that occur in chronic bronchitis.

Key term

Name the drug obtained from Theobroma cacao and state what it is used to treat.

Key term

Why must the people recruited to a trial be representative of the patients who will eventually take the drug?

Take Respiratory Diseases and Treatment further

The same content, four other ways.

Commonly confused

Pairs that lose marks when they are blurred together.

Chronic bronchitis vs Emphysema
Chronic bronchitis: long-term inflammation and swelling of the airways with excess mucus and destroyed cilia, giving a persistent cough that brings up sputum. Emphysema: breakdown of the elastin in the alveolar walls, so neighbouring air sacs merge into a few large spaces and the lungs cannot recoil.
Asthma vs COPD
Asthma: a reversible narrowing of the bronchioles that comes on in episodes, usually set off by an allergic trigger, and can be relieved within minutes. COPD: a progressive and irreversible obstruction of airflow caused by permanent structural damage, in most cases the result of smoking.
Beta agonist (reliever) vs Inhaled steroid (preventer)
Beta agonist (reliever): a drug that relaxes the smooth muscle of the bronchioles within minutes, widening the airway during an attack. Inhaled steroid (preventer): a drug taken every day that slowly suppresses the inflammation of the airway lining, and cannot stop an attack already under way.

Questions from this topic

Each one with the model answer underneath.

1
State three short-term effects of inhaling an irritant pollutant on the airways.
Model answer
The lining becomes inflamed, goblet cells secrete more mucus, and the smooth muscle of the bronchioles contracts so the airways narrow.
2
Explain the short-term effect of tobacco smoke on the ciliated epithelium of the airways.
Model answer
Chemicals in the smoke paralyse and then destroy the cilia, so mucus containing trapped dirt and bacteria is no longer swept up to the throat and collects in the airways instead.
3
Why does a smoker develop a persistent cough?
Model answer
Cilia are destroyed while mucus production is increased, so the only way to clear the accumulated mucus from the airways is by coughing.
4
Explain how the carbon monoxide in tobacco smoke reduces the oxygen supply to the tissues.
Model answer
Carbon monoxide binds to the haem groups of haemoglobin far more strongly than oxygen does, forming carboxyhaemoglobin, so fewer binding sites remain available to carry oxygen.
5
Name the component of tobacco smoke that contains carcinogens, and state where its long-term damage is seen.
Model answer
Tar, which deposits on the lining of the airways and causes mutations in the DNA of the bronchial epithelial cells, leading to lung cancer.
6
Name three long-term diseases of the respiratory system caused by tobacco smoke.
Model answer
Chronic bronchitis, emphysema and lung cancer.

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The Developing Cell: Cell Division and Cell Differentiation

The Developing Individual: Meiosis, Growth and Development

The Development of Species: Evolution and Classification

Cells and Microscopy

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measles and .

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Respiratory Diseases and Treatment revision questions

What does Respiratory Diseases and Treatment cover in OCR A-Level Biology B?: 4 subtopics: pollutants and the respiratory system, copd, asthma and lung cancer, treating asthma and medicinal drugs from plants and clinical trials and the role of nice. Each one has its own page with questions and model answers.
How is Respiratory Diseases and Treatment organised?: By the OCR H422 specification, subtopic by subtopic, so it matches the order you are taught it in.

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