Key term
CCEA A-Level Life and Health Sciences 0008
Experimental Techniques
Human Body Systems
Topic overviewBlood vessels, the heart and cardiac outputHeart sounds, ECG traces, pulse and blood pressureBody fluids, haemoglobin and the Bohr effectThe respiratory system, gas exchange and lung diseaseMonitoring breathing and lung volumesCellular respiration and ATPHomeostasis, blood glucose and thyroxineSodium, blood pH and oxygen saturationA balanced diet and nutritional needs through lifeCholesterol, minerals, vitamins, alcohol and exercise
Physical Chemistry in Industrial Processes
Topic overviewMoles, reacting masses and percentage yieldTitration types, indicators and standard solutionsTitration calculations and molarityEnthalpy changes and calorimetryHess's law and average bond enthalpiesCollision theory, rates and the Maxwell–Boltzmann distributionCatalysts, chemisorption and catalytic convertersReversible reactions, the Haber process and the Contact processScale-up, costs and siting a chemical plant
Brain ScienceDouble Award
Topic overviewBrain structure and frontal lobe damageNeurones, synapses and the endocrine systemAlzheimer's disease, Huntington's disease and stem cell therapySchizophrenia and mental health awareness in Northern IrelandThe biology of aggression and methods of studying the brainStress, the stress response and stress managementMemory models, forgetting and eyewitness testimonyAbnormality, phobias, depression and OCDExperiments, observations, self-report and research designHypotheses, sampling, ethics and descriptive statistics
Material ScienceDouble Award
Topic overviewMaterial properties and selectionStress, strain and the Young modulusStress–strain graphs, creep and fatigueDensity, hardness and conductivity testingMetals, ceramics, glasses, polymers and compositesAtomic and microscopic structure of materialsAlloys, annealing and biomaterialsSmart materialsNanomaterials and semiconductors
Medicine, Drugs and Clinical TrialsDouble Award
Topic overviewCategories of medicine and routes to drug discoveryMedicines from natural sources, drug names and the ATC systemDrug development, preclinical testing and the therapeutic indexPhases of clinical trials and trial designLicensing, UK regulators, Yellow Card and trial ethicsFormulations, routes of administration and drug absorptionDistribution, metabolism, elimination and sites of drug actionQuantitative analysis of medicines and antibacterial bioassays
Scientific Method, Investigation, Analysis and Evaluation
Topic overviewThe scientific method, literature reviews and Harvard referencingDescriptive statistics and the normal distributionNull hypotheses, significance and choosing a statistical testInvestigation design, Design of Experiments and project plansGood Laboratory Practice, risk assessment and COSHHExperimental error, scientific writing and evaluation
Organic Chemistry
Topic overviewOrganic formulae, homologous series and functional groupsIUPAC naming and types of organic reactionStructural isomerism and E/Z isomerismAlkanes from crude oil, combustion and halogenationVehicle pollutants, catalytic converters and biofuelsAlkenes, pi bonds and electrophilic additionClassifying alcohols, making ethanol and its effects as a drugOxidation of alcohols, IR spectroscopy and mass spectrometryAddition polymers, plastic waste and nylonPreparing and purifying aspirin
Medical PhysicsA2 option
Topic overviewBody temperature and clinical thermometersBlood pressure readings and the sphygmomanometerHeart activity experiments and EEG tracesX-ray tubes, radiographs and CT scansFlexible endoscopes, optical fibres and lasersUltrasound A-scans, B-scans and acoustic impedanceMRI scanning and gamma camera imagingAlpha, beta and gamma radiation and half-lifeRadiopharmaceuticals, radiotherapy and radiation protection
Sound and LightA2 option
Topic overviewTransverse and longitudinal waves and wave graphsPhase difference and the electromagnetic spectrumOuter, middle and inner earSound intensity and the decibel scaleStanding waves, harmonics and resonance tubesHearing response, phons and equal loudness curvesStructure of the eye, rods and conesAccommodation, lens power and correcting long sightTotal internal reflection and fibre-optic communicationDipole antennas, wireless networks and radarAttenuation of radio waves and the Doppler effect
Genetics, Stem Cell Research and CloningA2 option
Topic overviewDNA structure and the evidence for the double helixRNA, genes and the triplet codeGenotype, phenotype and monohybrid inheritanceDihybrid crosses, epistasis and the chi-squared testDNA replication and the Meselson–Stahl experimentMeiosis and genetic variationInsulin, factor VIII and chymosin from genetically modified microbesRecombinant DNA technology and gene cloningGenetic engineering, food supply and ethicsGene therapy and cystic fibrosisGenetic disease, screening and counsellingGenetic fingerprinting and gel electrophoresisStem cells, therapeutic cloning and their ethics
MicrobiologyDouble Award
Topic overviewBacteria, fungi and protozoaViruses, viroids and prionsClassifying bacteria, fungi and virusesLight and electron microscopyLaboratory safety, biocontainment and quality assuranceAseptic technique, growth media and inoculationCounting and measuring microbial growthGrowth requirements and growth inhibitionAntibiotics, PCR, gene therapy and pharmaceutical microbiologyThe gut microbiome in health and disease
Oral Health and DentistryDouble Award
Histology and PathologyDouble Award
Topic overviewSpecimen processing, data protection and safety lawClinical biochemistry tests and electrophoresisBlood smears and identifying blood cellsBlood grouping, cross-matching and transfusionDiagnostic and surveillance work in hospital microbiologyPreparing and staining tissue sectionsRecognising tissues, atheroma and emphysema on slides
Analytical Chemistry TechniquesDouble Award
Topic overviewVolumetric analysis in industry and healthcareApplied titrations of vinegar, indigestion tablets and bleachRedox titration of iron tablets and evaluating titrationsPrinciples of colorimetryColorimetric analysis of copper ore, aspirin and ironThin-layer chromatography and its usesVisualising chromatograms and identifying painkillers and pigmentsCalorimetry and combustionMolar enthalpy and bond energy calculationsQualitative tests for cations and gases
Enabling TechnologyDouble Award
Topic overviewECG and EEG machines in patient monitoringUltrasound and IVF equipment in fertility treatmentProsthetic limbs, hearing aids and cochlear implantsWorkflow and equipment in a medical laboratoryOngoing monitoring of a long-term conditionHealth data collection, databases and data protection
Microbiology
Growth requirements and growth inhibition
- 3 things to know
- A2 6
Overview
Nutrients, oxygen, temperature, light, pH and surfaces, inhibition by osmotic potential, irradiation, antibiotics, antifungals and antivirals, zones of inhibition and comparing growth monitoring methods.
What you need to know
Answer each one before you reveal it.
Your recallNot started
Key term
How does oxygen availability affect microbial growth?
Key term
How does temperature affect microbial growth?
Questions from this subtopic
Each one with the model answer underneath.
- 1
What nutrients do bacteria and fungi need to grow?
Model answer
Bacteria and fungi need a carbon source such as glucose and a nitrogen source for proteins. Minerals, water and sometimes vitamins are also needed.
- 2
How does oxygen availability affect microbial growth?
Model answer
Aerobes grow only with oxygen, and obligate anaerobes are killed by it. Facultative anaerobes grow in either condition.
- 3
How does temperature affect microbial growth?
Model answer
Growth is fastest at an optimum temperature, which is about 37 °C for many human pathogens. High temperatures denature enzymes, and low temperatures slow growth.
- 4
Why does light matter for some microorganisms but not others?
Model answer
Photosynthetic microorganisms, such as algae and cyanobacteria, need light to make food. Most bacteria and fungi grow without light.
- 5
How does pH affect the growth of bacteria and fungi?
Model answer
Most bacteria grow best near neutral pH. Many fungi prefer slightly acidic conditions, which is why fruit and bread go mouldy.
- 6
Why do growth surfaces matter to microorganisms?
Model answer
Many microorganisms attach to surfaces and form biofilms. Biofilms on medical devices such as catheters resist antibiotics and are hard to remove.
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