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Addictive Behaviours

Biological explanations: Addiction genes and Disease of the brain

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  • Component 3 Applications

Overview

Recall questions on Addiction genes and Disease of the brain.

What you need to know

Answer each one before you reveal it.

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Process

Name the three stages of the addiction cycle described by Koob and Volkow (2010).

Key term

Explain the logic that allows a twin study to separate genetic from environmental influence.

Who and when

Which dopamine receptor gene variant did Blum et al. (1990) report as more frequent in people with severe alcoholism?

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    What does the addiction-genes explanation claim?

    Model answer

    That inherited variation in genes affecting neurotransmission, drug metabolism and temperament makes some people far more likely to become addicted than others with the same exposure.

  2. 2

    Roughly what share of the variation in liability to alcohol dependence do twin and adoption studies attribute to genes?

    Model answer

    About half, according to the meta-analysis by Verhulst, Neale and Kendler (2015).

  3. 3

    Explain the logic that allows a twin study to separate genetic from environmental influence.

    Model answer

    Monozygotic twins share all their genes while dizygotic twins share about half, so a higher concordance in the identical pairs raised in the same home points to a genetic contribution.

  4. 4

    Which dopamine receptor gene variant did Blum et al. (1990) report as more frequent in people with severe alcoholism?

    Model answer

    The A1 allele of the DRD2 gene.

  5. 5

    What is reward deficiency syndrome?

    Model answer

    Blum's proposal that people with fewer D2 dopamine receptors get less pleasure from everyday rewards and so pursue drugs or gambling to lift dopamine to a normal level.

  6. 6

    Explain how the ALDH2 variant common in parts of East Asia protects against alcohol dependence.

    Model answer

    It slows the breakdown of acetaldehyde, so drinking causes flushing, nausea and palpitations, and that unpleasant reaction discourages heavy drinking.

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