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Addictive Behaviours

Biological explanations: Dopamine

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Recall questions on Biological explanations: Dopamine.

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Key term

Name the pathway at the centre of the dopamine explanation and the two structures it connects.

Key term

Explain the causal problem with scans showing fewer D2 receptors in addicted people.

Who and when

What did Alexander's Rat Park studies suggest about a purely pharmacological account of addiction?

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    Name the pathway at the centre of the dopamine explanation and the two structures it connects.

    Model answer

    The mesolimbic pathway, running from the ventral tegmental area to the nucleus accumbens.

  2. 2

    What did Olds and Milner (1954) demonstrate?

    Model answer

    Rats pressed a lever at very high rates to deliver electrical stimulation to a septal region of their own brains, giving the first direct evidence of a brain reward system.

  3. 3

    Explain how cocaine raises synaptic dopamine.

    Model answer

    It blocks the dopamine transporter that normally takes dopamine back into the presynaptic neuron, so dopamine stays in the cleft and its effect is prolonged.

  4. 4

    Explain how nicotine raises dopamine in the nucleus accumbens.

    Model answer

    It binds to nicotinic acetylcholine receptors on ventral tegmental area neurons, increasing their firing and so increasing dopamine release downstream.

  5. 5

    If a drug repeatedly floods the synapse with dopamine, how does the brain adapt and what follows?

    Model answer

    It reduces the number and sensitivity of dopamine receptors, so ordinary rewards feel flat and larger doses are needed, producing tolerance and low mood between uses.

  6. 6

    What distinction do Robinson and Berridge (1993) draw in incentive-sensitisation theory?

    Model answer

    Between wanting and liking: repeated use sensitises the dopamine wanting system so craving grows, even while the pleasure actually obtained from the drug declines.

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