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Schizophrenia

Methods of modifying the behaviour: Antipsychotic drugs

  • 3 things to know
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Recall questions on Methods of modifying the behaviour: Antipsychotic drugs.

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Key term

What do antipsychotic drugs mainly act on?

Key term

Name two first-generation antipsychotics and state their main action.

Key term

What are extrapyramidal side effects?

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    What do antipsychotic drugs mainly act on?

    Model answer

    The dopamine system; all effective antipsychotics block dopamine D2 receptors to some degree.

  2. 2

    Name two first-generation antipsychotics and state their main action.

    Model answer

    Chlorpromazine and haloperidol, both of which are strong D2 receptor antagonists.

  3. 3

    Which symptoms do first-generation antipsychotics treat best?

    Model answer

    Positive symptoms such as hallucinations and delusions; they do considerably less for negative and cognitive symptoms.

  4. 4

    What are extrapyramidal side effects?

    Model answer

    Movement disorders caused by dopamine blockade outside the target pathways, including muscle stiffness, tremor, restlessness and involuntary muscle spasms.

  5. 5

    What is tardive dyskinesia and why is it especially serious?

    Model answer

    It is a pattern of involuntary repetitive movements, typically of the face and mouth, developing after prolonged treatment, and it may persist even after the drug is stopped.

  6. 6

    How do second-generation antipsychotics differ from first-generation ones?

    Model answer

    They act on serotonin receptors as well as dopamine receptors and generally carry a lower risk of movement disorders, though metabolic side effects such as weight gain and diabetes are more common.

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