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Autistic Spectrum Behaviours

Biological explanations: Genetic predisposition

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Overview

Recall questions on Biological explanations: Genetic predisposition.

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Who and when

What did Folstein and Rutter (1977) find in the first twin study of autism?

Numbers

What is the recurrence rate in younger siblings of an autistic child?

Key term

Name two single-gene conditions in which autism is common.

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    What did Folstein and Rutter (1977) find in the first twin study of autism?

    Model answer

    Concordance was 36% in monozygotic pairs and 0% in dizygotic pairs, the first clear evidence of a substantial genetic contribution.

  2. 2

    What did Bailey et al. (1995) add to the twin evidence?

    Model answer

    In a larger British sample, monozygotic concordance was about 60% for autism itself and over 90% for a broader spectrum of related difficulties, against much lower dizygotic rates.

  3. 3

    What is the recurrence rate in younger siblings of an autistic child?

    Model answer

    Around 19% in the prospective study by Ozonoff et al. (2011), far above the population rate.

  4. 4

    Why is autism described as polygenic?

    Model answer

    Hundreds of common variants of small effect, together with rarer new mutations and copy number variants, contribute to liability; there is no single autism gene.

  5. 5

    Name two single-gene conditions in which autism is common.

    Model answer

    Fragile X syndrome and tuberous sclerosis.

  6. 6

    What has been reported about paternal age?

    Model answer

    Older paternal age is associated with a modestly raised likelihood of autism in the child, which is attributed to a greater number of new mutations arising in sperm.

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