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Addictive Behaviours

Methods of modifying the behaviour: Agonist and antagonist substitution

  • 3 things to know
  • Component 3 Applications

Overview

Recall questions on Agonist substitution and antagonist substitution.

What you need to know

Answer each one before you reveal it.

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Key term

Define an antagonist.

Key term

Name the agonist most widely used in opiate dependence and describe how it is given.

Key term

How does nicotine replacement therapy follow the agonist principle?

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    Define an agonist.

    Model answer

    A substance that binds to a receptor and activates it, producing the same kind of effect as the natural transmitter or the drug of dependence.

  2. 2

    Define an antagonist.

    Model answer

    A substance that binds to a receptor and blocks it without activating it, so the drug of dependence can no longer produce its effect.

  3. 3

    What is agonist substitution?

    Model answer

    Replacing the drug of dependence with a longer-acting, safer drug acting at the same receptors, given in a controlled dose so that withdrawal and craving are prevented without the peaks of intoxication.

  4. 4

    Name the agonist most widely used in opiate dependence and describe how it is given.

    Model answer

    Methadone, taken orally as a single measured daily dose, usually supervised at a pharmacy.

  5. 5

    What is buprenorphine, and why is it regarded as safer than methadone in overdose?

    Model answer

    It is a partial agonist at opioid receptors whose depressant effect on breathing reaches a ceiling, so increasing the dose does not go on suppressing respiration indefinitely.

  6. 6

    How does nicotine replacement therapy follow the agonist principle?

    Model answer

    Patches, gum and lozenges deliver nicotine, an agonist at nicotinic receptors, slowly and without tobacco smoke, so withdrawal is eased while the smoking behaviour itself is dropped.

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