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Autistic Spectrum Behaviours

Biological explanations: Amygdala dysfunction and Chloride ions at birth

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Key term

In Tyzio et al.'s (2014) rodent study, what happened when the mothers were pretreated with the diuretic bumetanide?

Key term

What has happened to bumetanide as a treatment in humans?

Key term

Which structures make up the social brain in this account?

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    State the amygdala theory of autism.

    Model answer

    Baron-Cohen et al. (2000) proposed that the amygdala, part of a wider social brain, develops and functions atypically, so that faces, eye gaze and emotional significance are processed differently.

  2. 2

    Which structures make up the social brain in this account?

    Model answer

    The amygdala, the orbitofrontal cortex and the superior temporal sulcus.

  3. 3

    What did Baron-Cohen et al. (1999) find in their fMRI study using the Eyes Task?

    Model answer

    Autistic adults showed less amygdala activation than comparison participants while judging mental states from photographs of the eye region, and recruited frontal areas instead.

  4. 4

    What did Schumann and Amaral (2006) report about the adult amygdala?

    Model answer

    Post-mortem analysis found fewer neurons in the amygdala of autistic adults than in comparison brains.

  5. 5

    What unusual growth pattern has been reported for the amygdala in autistic children?

    Model answer

    Early overgrowth in the first years of life followed by a relative levelling off, so the age at which a study measures the structure strongly affects what it finds.

  6. 6

    How would amygdala differences explain reduced eye contact?

    Model answer

    The amygdala assigns emotional significance to faces and drives fixation on the eyes, so an atypical response could make looking at eyes either less rewarding or actively uncomfortable.

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