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Schizophrenia

Biological explanations: Cannabis, genetics and the diathesis-stress model

  • 3 things to know
  • Component 3 Applications

Overview

Evidence linking cannabis to psychosis from D'Souza, the Swedish conscript study, Arseneault and Di Forti, family, twin and genome studies, and how the diathesis-stress model combines biological and environmental factors.

What you need to know

Answer each one before you reveal it.

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Who and when

What did the Swedish conscript study by Andreasson and colleagues (1987) find?

Who and when

What did Arseneault and colleagues (2002) add about age of use?

Who and when

What did Di Forti and colleagues (2019) report about cannabis potency?

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    What did D'Souza and colleagues (2004) demonstrate?

    Model answer

    Administering THC to healthy volunteers produced transient positive and negative symptoms together with cognitive impairment, which resolved afterwards.

  2. 2

    What did the Swedish conscript study by Andreasson and colleagues (1987) find?

    Model answer

    Men reporting heavy cannabis use at conscription were substantially more likely to receive a diagnosis of schizophrenia in the following years.

  3. 3

    What did Arseneault and colleagues (2002) add about age of use?

    Model answer

    Cannabis use beginning in early adolescence was associated with a greater increase in risk than use beginning later, suggesting the developing brain is more vulnerable.

  4. 4

    What did Di Forti and colleagues (2019) report about cannabis potency?

    Model answer

    Daily use of high-potency cannabis was associated with a much greater likelihood of a first episode of psychosis, and rates differed between cities according to the type of cannabis available.

  5. 5

    Give one reason the cannabis-psychosis association may not be causal.

    Model answer

    People in the early stages of psychosis may use cannabis to relieve distressing experiences, so the drug use could be a consequence rather than a cause.

  6. 6

    What pattern do family, twin and adoption studies of schizophrenia show?

    Model answer

    Risk rises with closeness of genetic relationship to an affected person and is far higher in identical than in non-identical twins, but concordance falls well short of complete.

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