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Stress

Biological explanations: Stress genes

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Why is Caspi's serotonin transporter finding now treated cautiously?

Questions from this subtopic

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  1. 1

    What is claimed by the stress genes explanation?

    Model answer

    That inherited variation contributes to how strongly and how long a person's stress systems react, and therefore to their vulnerability to stress-related illness.

  2. 2

    What do twin studies suggest about stress reactivity?

    Model answer

    That there is a modest to moderate genetic contribution to physiological stress reactivity, with the remaining variation attributable to environment and experience.

  3. 3

    What was claimed about the serotonin transporter gene?

    Model answer

    Caspi and colleagues (2003) reported that people carrying the short variant were more likely to become depressed following stressful life events, an apparent gene-environment interaction.

  4. 4

    What does the FKBP5 gene do?

    Model answer

    It regulates the sensitivity of glucocorticoid receptors, and so affects how efficiently the cortisol response is switched off.

  5. 5

    What is the current view of the genetics of stress vulnerability?

    Model answer

    That it is polygenic, involving many genes of very small individual effect, so there is no single stress gene.

  6. 6

    What did Weaver and colleagues (2004) show in rats?

    Model answer

    Pups receiving more maternal licking and grooming showed chemical changes to the gene controlling glucocorticoid receptors and a calmer stress response for life, demonstrating an epigenetic effect of early care.

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