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The Neuromuscular System

Muscle structure and the sliding filament theory

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Overview

Muscle structure down to the myofibril, the sarcomere, actin and myosin, tropomyosin and troponin, calcium ions and the sarcoplasmic reticulum, cross-bridges and the power stroke, and the five stages of contraction.

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What happens in the excitation stage?

Key term

Describe the structure of a skeletal muscle down to the myofibril.

Key term

Define the term sarcomere.

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    Describe the structure of a skeletal muscle down to the myofibril.

    Model answer

    A skeletal muscle is made of bundles of muscle fibres called fascicles. Each muscle fibre contains many myofibrils, divided along their length into sarcomeres.

  2. 2

    Define the term sarcomere.

    Model answer

    A sarcomere is the contractile unit of a myofibril, running from one Z line to the next.

  3. 3

    What are actin and myosin?

    Model answer

    Actin is the thin protein filament and myosin is the thick protein filament. Myosin carries heads that bind to actin to form cross-bridges.

  4. 4

    What is the role of tropomyosin?

    Model answer

    Tropomyosin is a thread-like protein lying along the actin filament. Tropomyosin covers the myosin-binding sites on actin while the muscle is at rest.

  5. 5

    What is the role of troponin?

    Model answer

    Troponin is a globular protein attached to tropomyosin. Calcium ions bind to troponin and change its shape, pulling tropomyosin away from the binding sites.

  6. 6

    Where are the calcium ions for contraction stored, and what releases them?

    Model answer

    Calcium ions are stored in the sarcoplasmic reticulum. An action potential arriving through the T-tubules triggers their release into the sarcoplasm.

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