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Issues in Mental Health

Biological treatments: antipsychotics, SSRIs and ECT

  • 3 things to know
  • Component 03

Overview

Recall questions on biological treatments including typical and atypical antipsychotics for schizophrenia, clozapine, extrapyramidal side effects and tardive dyskinesia, relapse, negative symptoms, adherence, evaluation of drug treatment, SSRIs for depression, and electroconvulsive therapy.

What you need to know

Answer each one before you reveal it.

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Key term

A family complain that medication has not lifted their son's flat mood and withdrawal. How would you explain this to them?

Key term

Name a typical antipsychotic and state which symptoms it mainly relieves.

Key term

What is the rationale for treating schizophrenia with antipsychotic drugs?

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    What is the rationale for treating schizophrenia with antipsychotic drugs?

    Model answer

    If the symptoms arise from excessive dopamine activity, then reducing the action of dopamine in the brain should reduce the symptoms.

  2. 2

    How do typical, first-generation antipsychotics work?

    Model answer

    They act as dopamine antagonists, binding to and blocking D₂ receptors so that dopamine can no longer stimulate the postsynaptic neuron.

  3. 3

    Name a typical antipsychotic and state which symptoms it mainly relieves.

    Model answer

    Chlorpromazine is a typical antipsychotic and it mainly reduces positive symptoms such as hallucinations and delusions.

  4. 4

    How does the action of atypical antipsychotics differ?

    Model answer

    They occupy dopamine receptors more briefly and also act on serotonin receptors, which brings some benefit for negative symptoms and mood with fewer movement side effects.

  5. 5

    Name two atypical antipsychotics.

    Model answer

    Clozapine and risperidone.

  6. 6

    Which drug is reserved for treatment-resistant schizophrenia, and why do patients taking it need regular blood tests?

    Model answer

    Clozapine is reserved for treatment-resistant cases, and regular blood tests are needed because it can cause agranulocytosis, a dangerous fall in white blood cells.

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