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Issues in Mental Health

The biochemical explanation of mental illness

  • 3 things to know
  • Component 03

Overview

Recall questions on the medical model's central assumption, the biochemical explanation, the original and revised dopamine hypotheses and their evidence, the monoamine hypothesis, cortisol in depression, the delay in antidepressant action, and the treatment aetiology fallacy.

What you need to know

Answer each one before you reveal it.

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Key term

Give two pieces of evidence supporting the dopamine hypothesis.

Key term

Which hormone is found at raised levels in many depressed patients?

Key term

Why is the time course of antidepressant action a problem for the biochemical explanation?

Questions from this subtopic

Each one with the model answer underneath.

  1. 1

    State the central assumption of the medical model.

    Model answer

    It assumes that mental disorders are illnesses with physical causes in the body, particularly the brain, and should be diagnosed and treated in the same way as any other physical illness.

  2. 2

    What does the biochemical explanation propose?

    Model answer

    It proposes that mental disorders result from imbalances in neurotransmitters or hormones which disturb the way messages pass between neurons.

  3. 3

    What does the original dopamine hypothesis claim?

    Model answer

    It claims that excessive dopamine activity, or oversensitive dopamine receptors, in subcortical areas such as the limbic system produces the positive symptoms of schizophrenia.

  4. 4

    How does the revised dopamine hypothesis account for negative symptoms?

    Model answer

    It proposes that dopamine activity is abnormally low in the prefrontal cortex at the same time as it is abnormally high in subcortical areas, and this underactivity produces the negative symptoms.

  5. 5

    Give two pieces of evidence supporting the dopamine hypothesis.

    Model answer

    Amphetamines raise dopamine activity and can produce psychotic symptoms in healthy people, and the drugs that reduce positive symptoms work by blocking dopamine receptors.

  6. 6

    What does the monoamine hypothesis say about depression?

    Model answer

    It says depression is caused by low levels or low activity of the monoamine neurotransmitters, particularly serotonin and noradrenaline.

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